Clinical Research

AIM

To work with regional, rural and remote clinicians practicing in the field of orthopaedics advancing research outcomes to benefit rural populations. 

Project contact

A/Prof Srinivas Kondalsamy Chennakesavan

Findings and outcomes to date

Wall C, Lee S, Ma Y, de Steiger R, Vertullo C, Kondalsamy-Chennakesavan S (In Press) Do patients with osteoarthritis lose weight prior to elective joint replacement? ANZ Journal of Surgery

Wall C, Vertullo C, Gill D, Page R, Holder C, Smith P (In Press)  Reduced numbers of elective joint replacement procedures in Australia during the COVID - 19 pandemic, 2020-2022: a registry data analysis study. Medical Journal of Australia

Vercruysse L. Y. G, Milne L. P, Harries D. T. C, de Steiger R. N, Wall C. J. (2024) Lower Revision Rates and Improved Stability With a Monoblock Ceramic Acetabular Cup. Journal of Arthroplasty, 39(4): 985-990

Flaaten N, Moslim H, Tang ER, Varrall R (2024) Scapular fractures: A regional and rural perspective. Australian Journal of Rural Health, doi:10.1111/ajr.13100

Wall C, Byrnes J, Botha L, Roe J (2023) Acute sport-related knee injuries. Australian Journal of General Practice. 52(11): 761-766

Nicol R, Lin I, Prasad L (2023) Biceps muscle injury associated with non-invasive automatic blood pressure monitoring. BMJ Case reports, 16(8): e256459

Crookes T, Wall C, Byrnes J, Johnson T, Gill D. (2023) Chronic shoulder pain. Australian Journal of General Practice. 52(11): 753-758

Vercruysse L, Milne L, Harries D, de Steiger R, Wall C (2023) Lower Revision Rates and Improved Stability With a Monoblock Ceramic Acetabular Cup. Journal of Arthroplasty, 39(4):985-990

Truong A, Wall C, Stoney J, Graves S, Lorimer M, de Steiger R (2023) Obesity is associated with an increased risk of undergoing hip replacement in Australia. ANZ Journal of Surgery, 93(7-8): 1901-1906

Morgan S, Wall C, de Steiger R, Graves S, Lorimer M, Page R (2023) Obesity is associated with an increased risk of undergoing shoulder arthroplasty in Australia. Journal of Shoulder and Elbow Surgery, 32(8): 1740-1745

Wall C, de Steiger R, Mulford J, Lewis P, Campbell D (2023) Perception of Perioperative Risk for Arthroplasty Patients: A Poll of Australian Orthopedic Surgeons. Journal of Arthroplasty, 38(8): 1418-1422

Wall C, Vertullo C, Kondalsamy-Chennakesavan S, Lorimer M, de Steiger R. (2022). A prospective, longitudinal study of the influence of obesity on total knee arthroplasty revision rate: Results from the Australian Orthopaedic Association National Joint Replacement Registry. J Bone Joint Surg Am, 104(15): 1386-1392

Aebischer A, Hau R, de Steiger R, Holder C, Wall C. (2022). Distal Femoral Replacement for Periprosthetic Fractures After TKA: Australian Orthopedic Association National Joint Replacement Registry Review. Journal of Arthroplasty, 37(7): 1354-1358

Johns N, Noye N, Wall C, Martin G, Loch A. (2022). Efficacy of adductor canal blocks in total knee arthroplasty. The Journal of Knee Surgery, 35(13): 1491-1494

Steadman W, Brown Z, Wall C. (2022). Minocycline black bone disease in arthroplasty: a systematic review. Journal of Orthopaedic Surgery and Research, 2022, 17: 295

Wall C, de Steiger R, Vertullo C, Stoney J, Graves S, Lorimer M, Kondalsamy‐Chennakesavan S. (2022). Obesity is associated with an increased risk of undergoing knee replacement in Australia. 92(7-8): 1814-1819

Truong A, Perez-Prieto D, Byrnes J, Monllau J, Vertullo C. (2022). Vancomycin Soaking Is Highly Cost-Effective in Primary ACLR Infection Prevention: A Cost-Effectiveness Study. The American Journal of Sports Medicine, 2022:10

Cook S, Wall C. (2021). Paget's disease of bone a clinical update. Australian Journal of General Practice, 50(1-2): 23-29

Aebischer A, Wing N, Wall C. (2021). Simultaneous total knee arthroplasty and proximal tibiofibular joing arthrodesis: A case report. JBJS Case Connector, 11(2): e20.00555

AIM

To investigate clinical practices in general medicine increasing research outcomes unique to regional, rural and remote populations.

Project contact

A/Prof Srinivas Kondalsamy Chennakesavan

A/Prof Matthew McGrail

Findings and outcomes to date

Khandaker G, Chapman G, Khan A, Al Imam M, Menzies R, Smoll N, Walker J, Kirk M, Wiley K (2024) Evaluating Pilot Implementation of 'PenCS Flu Topbar' App in Medical Practices to Improve National Immunisation Program-Funded Seasonal Influenza Vaccination in Central Queensland, Australia. Influenza and Other Respiratory Viruses, 18(4) e13280

Grimmett W. (2023). A reminder of the risk of burns with external heating devices in anaesthetised patients. Anaesthesia and Intensive Care, 51(3): 223-225.

Kitchener S. (2023). Did the coronavirus vaccination program in a rural and regional area work? Health outcomes of the vaccination program in Wide Bay. Australian Health Review, 47(1): 119-123

Jessup R, Bramston C, Putrik P, Haywood C, Tacey M, Copnell B, Cvetanovska N, Cao Y, Gust A, Campbell D, Oldenburg B, Mehdi H, Kirk M, Zucchi E, Semciw A, Beauchamp A (2023) Frequent hospital presenters' use of health information during COVID-19: results of a cross-sectional survey. BMC Health Services Research , 23(1): 616

Butson C, Kingon A, Quinn C, Ratsch A, Wan M. (2023). The dilemma of Pituri-further information for oral disease clinicians. Australian Dental Journal, 68(1): 70-71

Flynn D, Flynn H, Gifford S, Smith K. (2022). Can you hear me? Analysis of a Queensland patient-initiated escalation process and the importance of communication in surgical care. ANZ Journal of Surgery, 92(6): 1371-1376

Haga H, Tran E, Rieger N (2022) Colonoscopy quality of GP endoscopists in three rural hospitals in Queensland, Australia. Australian Journal of General Practice, 51(12): 979-985

Hamilton EM, Oversby S, Ratsch A, Kitchener S. (2022). COVID-19 Vaccination: An exploratory study of the motivations and concerns detailed in the medical records of a regional Australian population. Vaccines, 10(5): 657

Martyn J, Ratsch A, Cumming K & Dredge J. (2022). Methods of Detecting Medication Administration Point-of-Care Errors in Acute Adult Inpatient Settings: A Scoping Review Protocol. Methods and Protocols, 5(2): 32

Khan A, Green K, Smoll N, Khandaker G, Gartner C, & Lawler S. (2022). Roles, experiences and perspectives of the stakeholders of "10,000 Lives" smoking cessation initiative in Central Queensland: Findings from an online survey during COVID-19 situation. Health Promotion Journal of Australia, 33 (S1): 316-326

Chapman G, Al Imam M, Khan A, Smoll N, Adegbija O, Kirk M, Khandaker G, Wiley K. (2022). "Scary to get, more scary not to": COVID-19 vaccine acceptance among healthcare workers in Central Queensland, Australia, a cross sectional survey. Communicable Diseases Intelligence, 2022: 46

Dastouri D, McSweeney W, Sivananthan S. (2022). Situs inversus: an interesting case of spontaneous splenic rupture. Journal of Surgical Case Reports, 2022(2): 3

Choi MS, van der Mark MA, Hung K. (2022). The Distribution and Composition of Colonoscopy Providers in Australia. Cureus Journal of Medical Science, 14(2): 8

Smoll N, Khan A, Walker J, McMahon J, Kirk M, Khandaker G. (2021). A norovirus gastroenteritis outbreak in an Australian child-care center: A household-level analysis. PLOS One, 16(11): e0259145

Rickard C, Marsh N, Larsen E, McGrail M et.al. (2021). Effect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (central venous access device) - non-inferiority (peripheral arterial catheter) trial. The Lancet, 397(10283): 1447-1458

Walker J, Adegbija O, Smoll N, Khan A, Whicker J, Carroll H, Harris R, Ghandaker G. (2021). Epidemiology of mumps outbreaks and the impact of an additional dose of MMR vaccine for outbreak control in regional Queensland Australia, 2017-2018. Communicable Diseases Intelligence, 2021.45.67

Doherty Z, Fletcher J, Fuzzard K, Leach M, O'Sullivan B, Panozzo L, Pound G, Saka E, Kippen R. (2021). Functional outcomes following an in-hospital cardiac arrest: A retrospective cohort study. Australian Critical Care,  35(4): 424-429

Huang J, Phillips N, Nightingale J, Kondalsamy-Chennakesavan S, Grigg R, Mahendran S. (2021). Trans-oral robotic surgery - A safe and effective tool in head and neck surgery in an Australian rural setting. ANZ Journal of Surgery, 91(11): 2345-2351

Xujuan Z, Gururajan R, Yuefeng L, Venkataraman R, Xiaohui T, Ghazal B, Prabal B, Kondalsamy-Chennakesavan S. (2020). A survey on text classification and its applications. Web Intelligence, 18(3): 205-216

AIM

To better understand the needs of rural populations in relation to renal medicine and advance translatable research outcomes in this area, improving the health of regional Australia. 

Project contact

A/Prof Srinivas Kondalsamy Chennakesavan

A/Prof Matthew McGrail

Findings and outcomes to date

Thet Z, Lam A, Ng S, Aung S, Han T, Ranganathan D, Newsham S, Borg J, Pepito C, Khoo T (2024) Comparison of skin cancer risk between renal transplant recipients and patients with glomerular diseases in rural Queensland. Australian Journal of Rural Health, 32(2): 249-262

Thet Z, Lam A, Pham T, Ng S, Steel J, Sawhney S, Arellano C, Aung S, Han T, Ranganathan D, John G, Pepito C, Rautenberg T, Khoo T. (2023). Clinical and economic burden of benign and malignant skin lesions in renal transplant recipients. Internal Medicine Journal, 53(11): 2042-2049. 

Thet Z, Han T, Francis L, Aung N, Chau K, Ng S. K, Myint M, Borg J, Lam A, Khoo T, Ranganathan D (2023) Epidemiology of Glomerular Diseases in the Pre-and Post- COVID-19 Era in Central Queensland, Australia . Nephrology Dialysis Transplantation, 38(suppl 1): i380

Diwan V, Hoy W. E, Wang Z, Zhang J, Cameron A, Venuthurupalli S. K, Fassett R. G, Chan S, Healy H. G, Tan K. S, Baer R, Mallett A. J, Gray N, Mantha M, Cherian R, Mutatiri C, Madhan K, Kan G, Mitchell G, Hossain S, Wu D, Han T, Kark A, Titus T, Ranganathan D, Bonner A, Govindarajulu S (2023) Hospitalizations Among Adults With CKD in Public Renal Specialty Practices: A Retrospective Study From Queensland, Australia. Kidney Medicine, 5(9): art no. 100700

Strey G (2023) Second look diagnosis: dual sinus nodes rhythm in heart transplant patient. Medical Journal of Australia, 219(4): 152

Kelly M, Colbran R, Moar X. (2023). Sporadic visceral neuropathy of the large bowel. ANZ Journal of Surgery, 93(3): 718-719

White K, Neto A., Hurford R, Clement P, Laupland K, See E, McCullough J, White H, Shekar K, Tabah A, Ramanan M, Garrett P, Attokaran A. G, Luke S, Senthuran S, McIlroy P, Bellomo R, Queensland Critical Care Res, Network (2023) Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study. Intensive Care Medicine, 49: 1079-1089

Thet Z, Lam A, Ng S, Aung S, Han T, Ranganathan D, Newsham S, Borg J, Pepito C, Khoo T. (2022). An integrated skin cancer education program in renal transplant recipients and patients with glomerular disease. BMC Nephrology, 23(1), art no. 361

Ghannam M, Chau K, Han T, Forouzesh B, Thet Z. (2022). Antineutrophil Cytoplasmic Antibody (ANCA) Associated Glomerulonephritis and Lung Cancer: Disease Response to Novel Immunochemotherapy. Nephrology, 27: 77-78. 

Shugg N & Desai D. (2022). Augmented reality assistance for percutaneous nephrolithotomy: a scoping study. BJU International, 129: 80

Aljishi M, Pham T, Chan J, McGrail M, Han T, Borg J, Ranganathan D, Thet Z. (2022). Epidemiology of biopsy proven glomerular disorders and effect of severe cyclone on its incidence in Central Queensland region of Australia. Open Journal of Nephrology, 11(4): 477-488

Thet Z, Lam A, Ranganthan D, Aung S, Han T, Khoo T. (2022). Reducing non-melanoma skin cancer risk in renal transplant recipients. Nephrology, 26(11): 907-919

Mutatiri C, Ratsch A, McGrail M, Venuthurupalli S, Kondalsamy-Chennakesavan S. (2022). Referral patterns, disease progression and impact of the Kidney Failure Risk Equation (KFRE) in a Queensland chronic kidney disease Registry (CKD.QLD) cohort: a study protocol. BMJ Open, 12(2): e052790

Munasinghe A, Wedisinghe L, Han T, Nararyan R. (2021). Bilateral renal artery stenosis due to fibromuscular dysplasia presenting as superimposed pre-eclampsia. BMJ Case reports, 14(5): e237759

Gilbar P, Pokharel K. (2021). Severe cisplatin-induced renal toxicity in a patient with xeroderma pigmentosum. Journal of Oncology Pharmacy Practice, 28(2): 466-470

AIM

To showcase research excellence in progressing mental health research in regional, rural and remote Australian communities, with positive outcomes being implemented and the mental health of future generations safe guarded.

Project contact

A/Prof Srinivas Kondalsamy Chennakesavan

Findings and outcomes to date

Luthra S, Duggan L, Agrawal A, Kaur G, Luthra N (2024) Prevalence of High-dose Antipsychotic Prescribing in Schizophrenia: A Clinical Audit in a Regional Queensland Mental Health Service. International Journal of Applied and Basic Medical Research, 13(2): 70-76

Kenchaiah B, Cementon E, Padayachee S, Pascoe A, Reilly J (2023) Managing Comorbidity in your patients, towards an integrated and connected future: Focus on substance use disorders. Australian and New Zealand Journal of Psychiatry, 57(1): 16-17

MacAskill W, Hoffman B, Johnson M. A, Sharpe G. R, Rands J, Wotherspoon S, Gevorkov Y, Kolbe-Alexander T, Mills D (2023) The effects of age on dyspnea and respiratory mechanical and neural responses to exercise in healthy men. Physiological Reports, 11(16): art no. e15794

Brand E, Nagaraj D, Ratsch A, Heffernan E. (2022). A Qualitative Study on Sexuality and Sexual Experiences in Community Forensic Mental Health Patients in Queensland, Australia. Frontiers in Psychiatry, 13: 832139

Gill N, Parker S, Amos A, Lakerman R, Emeleus M, Brophy L, Kisely S. (2021). Opening the doors: Critically examining the locked wards policy for public mental health inpatient units in Queensland Australia. Australian and New Zealand Journal of Psychiatry, 55(9): 48674211025619-848

Karim R, Kwan M, Finlay A, Kondalsamy-Chennakesavan S, Toombs M, Nicholson G, McGrail M, Gill N. (2019). Mortality in hospital patients with and without mental disorders: a data-linkage cohort study. Journal of Psychiatric Research, 111: 104-109

AIM

To investigate patient outcomes and clinical practices in urology for regional, rural and remote populations, with translatable research outcomes being implemented in these communities. 

Project contact

A/Prof Matthew McGrail

Findings and outcomes to date

Chu Ann, Somani B. K, Teoh Yuen-Chun J, Tailly T, Tanidir Y, Gadzhiev N, Bin Hamri S, Keat Lay W. O, Shrestha A, Ragoori D, Lakmichi M.A, Gorelov D, Vaddi CM, Bhatia TP, Desai D (2024) Comparing Retrograde Intrarenal Surgery (RIRS) outcomes between pre-stented vs non-stented patients Inferences from 6679 patients of the global FLEXible ureteroscopy Outcomes Registry (FLEXOR). European Urology. 83(1): A1220

Harrison W, Ravichandran K, Munien K, Desai D (2024) Enhancing diagnostic value in urethral imaging: the case for urologist-performed urethrograms. Trends in Urology & Mens Health. doi: 10.1002/tre.957

Harrison W, Munien K, Desai D (2023) Advancements in minimally invasive bilateral ileal ureter replacement: a promising approach for complex long-segment ureteric strictures. Translational Andrology and Urology, 12(8): 1215-1218

Gauhar V, Chew B, Traxer O, Tailly T, Emiliani E, Inoue T, Tiong H, Chai C, Lakmichi M, Tanidir Y, Bin Hamri S, Desai D, et al. (2023). Indications, preferences, global practice patterns and outcomes in retrograde intrarenal surgery (RIRS) for renal stones in adults: results from a multicenter database of 6669 patients of the global FLEXible ureteroscopy Outcomes Registry (FLEXOR). World Journal of Urology, 41(2), 567-574.

Tariq A, Stewart A. G, Desai D, Britton S, Dunglison N, Esler R, Roberts M (2023) Periurethral abscess etiology, risk factors, treatment options, and outcomes: A systematic review. Current Urology, 17(2): 100-108

Kelly M, Colbran R, Moar X (2023) Sporadic visceral neuropathy of the large bowel. ANZ Journal of Surgery, 93(3): 718-719

Flynn H, Desai D (2022). Exploring the impact of buccal mucosal graft harvesting for urethroplasty on oral quality of life: A prospective study." BJU International, 129: 21-22

McNaught A & Lamparelli M. (2021). Rare combination of verrucous carcinoma and syringocystadenoma papilliferum in anterior perineal sinus: recognizing the absence of normality. ANZ Journal of Surgery, 91(11): E749-E750

Ong M, Duncan C, McGrail M, Desai D. (2020). Evaluation of patient reported outcome measures post urethroplasty: piloting a "trifecta" approach. World Journal of Clinical Urology, 9(1): 9-15

AIM

To work with emergency specialists in regional, rural and remote Australian, advancing processes, workflows, and clinical practices in meeting the needs of these geographically isolated communities.

Project contact

A/Prof Srinivas Kondalsamy Chennakesavan

Findings and outcomes to date

Schults J, Young E, Marsh N, Larsen E, Corley A, Ware R, Murgo M, Alexandrou E, McGrail M, Gowardman J, Charles K, 
Regli A, Yasuda H, Rickard C (2024) Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial. Journal of Intensive Care, 12(1): art no 12

Harrison W, Munien K, Desai D (2024) Robotic surgery education in Australia and New Zealand: primetime for a curriculum. ANZ Journal of Surgery, 94(1-2): 30-36

Padar M, Mudalige V (2023) Congenital diverticulum of the vermiform appendix: a rare finding of a routine operation. Journal of Surgical Case Reports, 2023(3): 2

Emerson P, Flabouris A, Thomas J, Fernando J, Senthuran S, Sundararajan K (2023) Intensive care utilisation after elective surgery in Australia and New Zealand: getting the balance right. Australian Health Review, 47(6): 718-720

Emerson P, Flabouris A, Thomas J, Fernando J, Senthuran S, Knowles S, Hammond N, Sundararajan K (2023). Intensive care utilisation after elective surgery in Australia and New Zealand: A point prevalence study. Critical Care and Resuscitation, 26(1):1-7

Chinthamuneedi R, Phaltane S, Chinthamuneedi M, Kondalsamy-Chennakesavan S, Cheung B (2023) Modifications to Rapid Response Team (Medical Emergency Team) activation criteria and its impact on patient safety. Intern Med Journal, 53(7): 1212-1217

Latona A, Hill K, Connelly A, Stuart K, Wood P. (2023). Prothrombinex®-VF in chronic liver disease: Friend or foe? EMA - Emergency Medicine Australasia, 35(1): 89-96.

Sykes B, Krause H, Lamparelli M, Austin D (2023) Saksenaea murcormycosis: a rare and dangerous cause of necrotising fascitis. BMJ Case reports, 16(3): e254183

Attokaran A, Ramanan M, Hunt L, Chandra K, Sandha R, Watts S, Venkatesh B (2023) Sodium chloride or plasmalyte-148 for patients presenting to emergency departments with diabetic ketoacidosis: A nested cohort study within a multicentre, cluster, crossover, randomised, controlled trial. Emergency Medicine Australasia, 35(4): 657-663

Hamilton E, Ngugi S, Kotakadeniya R. (2023) Surgical Management of Atraumatic Rupture of Splenic Artery Aneurysm with Spleen Preservation in a Regional Australian Hospital. Case Reports in Surgery, 2023: art no. 5738806

Michael A (2023) We must not sacrifice anaesthesia rotations as part of emergency medicine training. Emergency Medicine Australasia, 35(3): 517-518

Rana R, Gow J, Moloney C, King A, Keijzers G, Beccaria G, Mullens A. (2022). Does distance to hospital affect emergency department presentations and hospital length of stay among COPD patients?. Intern Medicine Journal, 52(3): 403-410

Flaaten N & Dyke G. (2022). First rib fracture: Still a marker of trauma severity? Emergency Medicine Australasia, 34(5): 808-811

Sweeny AL, Bourke C, Torpie TM, Sargeant S, Hughes J, Watson J, Conroy S, et al. (2022). Improving domestic violence screening practices in the emergency department: an Australian perspective. Emerg Med J, 2022: 1-6

Rana R, Gow J, Moloney C, King A, Keijzers G, Beccaria G, Mullens A. (2021). Estimating the frequency and cost of emergency department presentations and hospitalisation of chronic obstructive pulmonary disease patients: A retrospective analysis from regional Queensland. Emergency Medicine Australasia, 33 (3): 491-498

AIM

To improve regional, rural and remote women’s health outcomes by working with clinicians to advance research outcomes in women’s health.

Project contact

A/Prof Srinivas Kondalsamy Chennakesavan

Findings and outcomes to date

Hegerty C, Ostini R (2023) Benefits and harms associated with an increase in gestational diabetes diagnosis in Queensland, Australia: a retrospective cohort comparison of diagnosis rates, outcomes, interventions and medication use for two periods, 2011-2013 and 2016-2018, using a large perinatal database. Obstetrics & Gynaecology, 13 (5): e069849

Nguyen A, Siu R, Kleinschmidt G, Sood B, Shandiz E (2023) Epstein-Barr virus reactivation-related meningoencephalitis with transverse myelitis in pregnancy. Clinical Case Reports, 11(9): e7923

Barbier H, Carberry C, Karjalanien P, Mahoney C, Galan V, Rosamilia A, Ruess E, Shaker D, Thariani K (2023) International Urogynecology consultation chapter 2 committee 3: the clinical evaluation of pelvic organ prolapse including investigations into associated morbidity/pelvic floor dysfunction. International Urogynecology Journal, 34(11): 2657-2688

Ratsch A, Bogossian F, Burmeister E. A, Ryu B, Steadman K. J. (2022). Higher blood nicotine concentrations following smokeless tobacco (pituri) and cigarette use linked to adverse pregnancy outcomes for Central Australian Aboriginal pregnancies. BMC Public Health, 22(1):2157

Orevich LS, Watson K, Ong K, Korman I, Turner R, Shaker D, Liu YH. (2022). Morphometric and morphokinetic differences in the sperm- and oocyte-originated pronuclei of male and female human zygotes: a time-lapse study. Journal of Assisted Reproduction and Genetics, 39(1): 97-106

Liu Y, Ong K, Korman I, Turner R, Shaker D, Zander-Fox D, et al. (2022). The effect of day 5 blastocyst assessment timing on live birth prediction and development of a prediction algorithm. Reproductive Biomedicine Online, 44(4): 609-616

AIM

To better understand the health needs of regional, rural and remote children and provide translatable research outcomes to improve their health.

Project contact

A/Prof Srinivas Kondalsamy Chennakesavan

Findings and outcomes to date

Smoll N, Khan A, Walker J, McMahon J, Kirk M, Khandaker G. (2022). A norovirus gastroenteritis outbreak in an Australian child-care center: A household-level analysis. PLOS One, 16(11): e0259145

Petcu C, Stehr E, Isaac J, Desai D. (2021). Management of paediatric recurrent urinary tract infections and challenges in special patient populations. Australian Journal of General Practice, 50(7): 2021